가토에서 하악골신장술시 신장부에 대한 가골압축의 효과
Original Articles : Effects of Compression on Distracted Area During Mandibular Distraction In Rabbits
박홍주, 안진석, 국민석, 오희균, 유선열, 조진형,
소속 상세정보
박홍주 ( Park Hong-Ju ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
안진석 ( An Jin-Suk ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
국민석 ( Kook Min-Suk ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
오희균 ( Oh Hee-Kyun ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
유선열 ( Ryu Sun-Youl ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
조진형 ( Cho Jin-Hyoung ) - 전남대학교병원 교정과
KMID : 0360120070290010001
Abstract
Purpose: To evaluate the effect of compression on the distracted area in new bone formation during mandibular distraction osteogenesis in rabbits.
Materrials and Method: Sixteen rabbits, weighing approximately 2 Kg, and the prefabricated distraction device were used. With the rabbits under general anesthesia, we performed vertical osteotomies between the anterior and posterior mandibular teeth and then placed the distraction device. After a 5 -day latency period, the mandible was distracted to a length of 10.0 mm at a rate of 1 mm/day and then immediately compressed 4 mm in the experimental group (n=8). In the control group (n=8), the mandible was distracted to a length of 6.0 mm at a rate of 1 mm/day. Rabbits in the control group were killed at 2 and 8 weeks during the consolidation period. The specimens were evaluated with light microscope after H & E stain. Histomorphometric analysis was done at 8 week specimens.
Result: All experimental animals showed mandibular elongation on the macroscopical and radiographic evaluations. At 2 week, immature bone formation was observed from the surface of the host bone margins with collagen fibers arranged parallel to the direction of distraction in the control group; in the experimental group, immature bone formation was observed adjacent to the host bone, and the collagen fibers were not arranged uniformly. At 8 week, spindle-shaped new bone formation was seen in the direction of distraction in distracted area of the control group, while in the experimental group, the newly formed bone was arranged in a multidirectional manner, like the pattern of trabeculae. In the histomorphometric analysis of 8 weeks, the area of bone deposition was 2.12+/-0.75 inch(2) in the experimental group and 0.87+/-0.51 inch(2) in the control group (p<0.01). The bone deposition ratio was 29.60+/-10.50% in the experimental group and 12.10+/-7.17% in the control group (p<0.01).
Conclusion: These results suggest that compression after over-distraction during the mandibular distraction osteogenesis is an effective method of increasing the amount of newly formed bone in distracted area.
키워드
Distraction Osteogenesis;Compression
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